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Neurological disorders : new research [E-Book] - 1 online resource. - Neuroscience research process Neurology--laboratory and clinical research developments .

Includes bibliographical references and index.

NEUROLOGICAL DISORDERS ; NEUROLOGICAL DISORDERS ; Contents; Preface; Advanced Structural and Functional MRI Techniques in Parkinson's Disease; Abstract; Introduction; MR Morphometry; Diffusion MR Imaging; Functional MRI; Motor fMRI; Cognitive fMRI; Resting-State fMRI; Conclusion; References; Neuropoietic Cytokines and Neural Injury: Alterations in JAK2/STAT3 Signaling Associated with Aging; Abstract; 1. Introduction; 1.1. Neuropoietic Cytokine Family; 1.2. Role of the gp130 Cytokine Receptor Complex; 1.3. Role of Janus Kinases (Jaks) 1.4. Activation of Signal Transducer and Activator of Transcription 3 (STAT3)1.5. Effects of Phospho-STAT3 (pSTAT3); Cell Survival; Remodeling the Cellular Environment; Regulating Oxidative Stress; Immune Tolerance; Role of the Phosphorylation Site; 1.6. Regulating pSTAT3: Role of Negative Regulators; Suppressors of Cytokine Signaling (SOCS); Protein Inhibitors of Activated Stats (PIAS); Protein Tyrosine Phosphatases (PTP); 2. Discussion; 2.1. Changes in Neural Injury; Stroke; Traumatic Brain Injury; 2.2. JAK2/STAT3 Regulation Altered with Aging; 2.3. Significance of Phosphorylation Site. 3. Future Directions3.1. Elucidate the Role of STAT3 across Cell Types; 3.2. Modulating Beneficial vs. Detrimental Effects; 3.3. Identifying Injury-Associated Changes; 3.4. Understanding and Manipulating Regulatory Processes for Therapeutic Benefit; 3.5. The IL-6 and IL-10 Signaling Dynamic; 3.6. Therapeutic Development: Challenges of Inhibition; Conclusion; Acknowledgments; References; Neurological Complications Associated with Anti-Tumor Necrosis Factor Alpha (TNF-) Treatment; Abstract; Introduction; Tumor Necrosis Factor (TNF)-; Pathogenicity of TNF- in Neurological Disorder. Anti-TNF- or TNF- Antagonist DrugAnti-TNF- and Neurological Disorders; Conclusion; References; Effect of Aging on Changes of Nociception and Cav2 1 Expression Patterns in Seven Inbred Mouse Strains; Abstract; Introduction; Materials and Methods; Animals; Nociceptive Assays; Statistical Analysis of Behavioral Tests; Real-Time qRT-PCR Analysis; Results; Pain-Related Behavioral Tests; Expression Tests of Cav2 Family Members with Real-Time qRT-PCR Assay; Discussion; Conclusion; Acknowledgments; References; Polymeric Intracorporeal Devices for the Management of Neurological Disorders. Abstract1. Introduction; 2. Polymer-Based Implantable Devices for Major CNS Disorders; 2.1. Intracranial Implants; 2.1.1. Drug Delivery Approaches Employed to Traverse the Blood Brain Barrier; 2.1.1.1. Ethylene Vinyl Acetate Copolymers Avac as a Prototype; Biocompatible Polymer Employed for Local Drug Delivery to the Brain; 2.1.1.2. Silk-Based Polymers as an Alternative to Synthetic Drug Delivery-Systems for the Treatment of Epilepsy; 2.1.2. Application of Polymer-Based Implantable Devices in Parkinson's Disease; 2.1.2.1. Biocompatible Dopamine-Loaded Polymeric Matrix Device.

ISBN: 9781622570560 1622570561

LCCN: 2020686181

Subjects--Topical Terms:
Nervous system--Diseases.
Neurology.